| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5498006 | Applied Radiation and Isotopes | 2017 | 5 Pages |
Abstract
Yttrium-90 obtained from most of the 90Sr/90Y generators contains 90Sr impurity above permissible limit for human administration. A protocol has been optimized for formulation of therapeutic dose of 90Y-DOTA-Tyr3-octreotate (90Y-DOTA-TATE) and removal of 90Sr impurity from it. The radiochemical purity of 90Y-DOTA-TATE was found to be >98% and it met the requirements for clinical use. The radiopharmaceutical was used in preliminary clinical investigation in patients with neuroendocrine tumors. This promising strategy would aid toward widespread clinical utilization of 90Sr/90Y generators.
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Authors
Rubel Chakravarty, Sudipta Chakraborty, Ashutosh Dash,