Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5500633 | Ageing Research Reviews | 2017 | 25 Pages |
Abstract
The objective of this paper is to review current information regarding the treatment of age-related hearing loss by using cochlear hair cell regeneration. Recent advances in the regeneration of the inner ear, including the usefulness of stem cells, are also presented. Based on the current literature, cochlear cell regeneration may well be possible in the short term and cochlear gene therapy may also be useful for the treatment of hearing loss associated with ageing. The present review provide further insight into the pathogenesis of Inner Ear senescence and aged-related hearing loss and facilitate the development of therapeutic strategies to repair hair cells damaged by ageing. More research will be needed in order to translate them into an effective treatment for deafness linked to cochlear senescence in humans.
Keywords
SNHLNeurog1Oct4ASNPDGFLgrbHLHIPSCP27kip1ATOH1paired box gene 2BMP4Cyclin-dependent kinase inhibitor 1BMEFsNTF3NGFASCCDKbFGFFGFNgn1PCNACNTFFGF3BDNFProliferating Cell Nuclear Antigenbasic helix-loop-helixdocosahexaenoic acidAge-related hearing lossRegenerationESCDHAretinoblastomahair cellAdult stem cellInduced pluripotent stem cellEmbryonic stem cellsneuronal growth factorplatelet-derived growth factorfibroblast growth factorbasic fibroblast growth factorinsulin-like growth factor 1octamer-binding transcription factor 4Brain-derived neurotrophic factorciliary neurotrophic factorSex determining region Y-box 2mouse embryonic fibroblastsneurotrophin-3bone morphogenetic protein 4Rho-associated protein kinasesensorineural hearing losscyclin-dependent kinaseInner ear
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Miren Revuelta, Francisco Santaolalla, Olatz Arteaga, Antonia Alvarez, Ana Sánchez-del-Rey, Enrique Hilario,