Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5500732 | Ageing Research Reviews | 2017 | 11 Pages |
Abstract
Sirtuin 6 (SIRT6) is a member of the sirtuin family NAD+-dependent deacetylases with multiple roles in controlling organism homeostasis, lifespan, and diseases. Due to its complex and opposite functional roles, this sirtuin is considered a two-edged sword in health and disease. Indeed, SIRT6 improves longevity, similarly to the founding yeast member, silent information regulator-2 (Sir2), and modulates genome stability, telomere integrity, transcription, and DNA repair. Its deficiency is associated with chronic inflammation, diabetes, cardiac hypertrophy, obesity, liver dysfunction, muscle/adipocyte disorders, and cancer. Besides, pieces of evidence showed that SIRT6 is a promoter of specific oncogenic pathways, thus disclosing its dual role regarding cancer development. Collectively, these findings suggest that multiple mechanisms, to date not entirely known, underlie the intriguing roles of SIRT6. Here we provide an overview of the current molecular mechanisms through which SIRT6 controls cancer and heart diseases, and describe its recent implications in the atherosclerotic plaque development.
Keywords
AMPKSTAT3NF-κBα-SMACDKDSBTGF-β1IGFNFATICAEPCSCCNrf2UVBCOX-2RUNX2FOXO1ICAM-1MCP-1PPARγeNOSBERSIRSIRTsirtuinIGF-1JAK2HIF-1αGLP-1PGC-1αGLUT1PEPCKNRF1VSMCFOXO3PAI-1IL-8tert-butylhydroperoxideSNF2HVCAM-1Twist1CLLPCBP2G6PaseSREBPJanus Kinase 2NKG2DSIRT6PCSK9HNSCCnatural killer group 2Dosterixpoly [ADP-ribose] polymerase 1EGTDNA-PKPARP1ELK1H3K9Lin28bGCN5PKM2histone 3 lysine 9TRPM2pfk1CtIPinterleukine 8twist-related protein 1H3K56carboxyl terminus of HSP70-interacting proteinUSP10AMP-activated protein kinasecAMPERK1/2HCCMAPKMϕROSt-BHPAtherosclerosisCyclic adenosine monophosphateALPAlkaline phosphataseAngiotensin IIErgothioneineultraviolet Binsulin-like growth factor-1α-smooth muscle actinOsxinterleukineIcariincardiovascular diseaseCardiovascular diseasesTransforming growth factor-β1Triglyceridesbase excision repairsilent information regulatortumor necrosis factor-αEMTforkhead box O3LINE1Ang IICVDAgingCancerVascular smooth muscle cellsEndothelial progenitor cellsEndothelial cellsendothelial nitric oxide synthaseCyclooxygenase-2Lifespanhypoxia-inducible factor-1αNuclear respiratory factor 1Runt-related transcription factor 2nuclear factor of activated T-cellsTNF-αnuclear factor-kappaBnuclear factor erythroid 2-related factor 2phosphoenolpyruvate carboxykinasephosphofructokinase 1lactate dehydrogenaseLDHChronic lymphocytic leukemiaLow-density lipoproteinLDLMacrophagessignal transducer and activator of transcription 3Plasminogen activator inhibitor-1intercellular adhesion molecule-1MonocytesNADNOTCH3nicotinamide adenine dinucleotideDNA-dependent protein kinaseForkhead box protein O1monocyte chemoattractant protein-1Proprotein convertase subtilisin/kexin type 9Pyruvate kinase M2CHiPSquamous cell carcinomaHead and neck squamous cell carcinomaHepatocellular carcinomaextracellular signal-regulated kinase 1 and 2mitogen-activated protein kinasescyclin-dependent kinaseEpithelial-mesenchymal transitionglucagon-like-peptide-1glucose transporter 1glucose-6-phosphataseReactive oxygen speciesperoxisome proliferator-activated receptor γ
Related Topics
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Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Milena Vitiello, Alberto Zullo, Luigi Servillo, Francesco Paolo Mancini, Adriana Borriello, Alfonso Giovane, Fulvio Della Ragione, Nunzia D'Onofrio, Maria Luisa Balestrieri,