| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5500834 | Archives of Gerontology and Geriatrics | 2017 | 10 Pages |
Abstract
This study shows clear characteristics of sarcopenia that coincide with anabolic resistance, insulin resistance and oxidative stress in 25 month-old C57/BL6 male mice, similar to human ageing. Furthermore, similar decline in muscle mass, strength and function was observed in this aged-mice-model. These observations offer potential for the future to explore in old mice the effects of interventions targeting sarcopenia.
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Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Miriam van Dijk, Jolanda Nagel, Francina J. Dijk, Jerôme Salles, Sjors Verlaan, Stephane Walrand, Klaske van Norren, Yvette Luiking,