| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5500852 | Archives of Gerontology and Geriatrics | 2017 | 29 Pages |
Abstract
Memory impairment induced by isoflurane exposure is associated with dysregulated histone acetylation in the hippocampus, which affects BDNF expression and hence BDNF downstream signaling pathway. Apigenin recovers cognitive function by restoring histone acetylation and suppressing neuroinflammation.
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Authors
Lin Chen, Wenji Xie, Wenqin Xie, Weiqiang Zhuang, Changcheng Jiang, Naizhen Liu,