| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5500924 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2017 | 38 Pages |
Abstract
The decreased affinity of ApoA-I amyloidogenic variants for lipids, together with the increased efficiency in the cholesterol efflux process, could explain why, despite the unfavourable lipid profile, patients affected by ApoA-I related amyloidosis do not show a higher CVD risk.
Keywords
DLSPBSSRCDSRB1rHDLHDLLCATPoPCABCA1ApoA-IRCTdMPC1-Palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine1,2-dimyristoyl-sn-glycero-3-phosphocholinereconstituted HDLhigh-density lipoproteinAmyloidosisApolipoprotein A-ITevcardiovascular diseaseSynchrotron radiation circular dichroismCholesterol effluxCVDphosphate buffer salineLecithin:cholesterol acyltransferasewild-typeHypoalphalipoproteinemiaTobacco etch virusDynamic Light Scatteringreverse cholesterol transportscavenger receptor class B type 1
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Authors
Rita Del Giudice, Joan Domingo-EspÃn, Ilaria Iacobucci, Oktawia Nilsson, Maria Monti, Daria Maria Monti, Jens O. Lagerstedt,