Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5501002 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2017 | 35 Pages |
Abstract
The KD has tissue specific impacts on O-GlcNAc. Although levels of O-GlcNAc play an important role in neurodevelopment, levels of this modification in the juvenile mouse brain were stable with the KD despite large fluctuations in energy status. This suggests that it is unlikely that the KD exerts it therapeutic benefit in the BTBR model of ASD by O-GlcNAc related pathways.
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Christopher Newell, Virginia L. Johnsen, Nellie C. Yee, Warren J. Xu, Matthias S. Klein, Aneal Khan, Jong M. Rho, Jane Shearer,