| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5501115 | Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease | 2017 | 36 Pages |
Abstract
In conclusion, miR-190a down-regulation plays a role in MGO-induced endothelial insulin resistance by increasing KRAS. This study highlights miR-190a as new candidate for the identification of strategies aiming at ameliorating vascular function in diabetes.
Keywords
eNOSPHLPPmouse aortic endothelial cellsMAECsGLO1IRS-1HDACERKHUVECSKRASTSAPI3KmiRNAsMAPKAminoguanidineAktendothelial NO synthaseEndotheliumTrichostatin ADiabetes mellitusmicroRNAsinsulin receptor substrate 1Kirsten rat sarcoma viral oncogene homologHuman umbilical vein endothelial cellsAgePhosphatidylinositol 3-kinaseMethylglyoxalMEKAdvanced glycation end-productInsulin resistanceMgONitric oxidehistone deacetylaseprotein kinase Bmitogen-activated protein kinaseExtracellular signal-regulated protein kinaseGlyoxalase 1
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Paola Mirra, Cecilia Nigro, Immacolata Prevenzano, Teresa Procopio, Alessia Leone, Gregory Alexander Raciti, Francesco Andreozzi, Michele Longo, Francesca Fiory, Francesco Beguinot, Claudia Miele,