Article ID Journal Published Year Pages File Type
5501145 Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2017 37 Pages PDF
Abstract
Our results suggest that IL-6 induces utrophin expression in mdx myotubes through activation of a NRG-1/ErbBs signaling cascade. Soluble NRG-1 elicited by proteolytic processing of transmembrane NRG-1 might induce ErbBs phosphorylation and ERK1/2 pathway activation, leading to utrophin up-regulation.
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Life Sciences Biochemistry, Genetics and Molecular Biology Ageing
Preview
Interleukin-6 and neuregulin-1 as regulators of utrophin expression via the activation of NRG-1/ErbB signaling pathway in mdx cells
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