4-hydroxynonenal-mediated signaling and aging

•HNE concentration in the plasma and cells/tissues increases with aging.•HNE regulates NF-κB signaling in concentration-dependent manner.•HNE contributes to aging-related decline in Nrf2 signaling response.•HNE causes aging-related variation of AKT signaling via PTEN and others.•HNE alters aging-related mTORC1 signaling through LKB1, AMPK and others.

4-Hydroxy-2-nonenal (HNE), one of the major α, β-unsaturated aldehydes produced during lipid peroxidation, is a potent messenger in mediating signaling pathways. Lipid peroxidation and HNE production appear to increase with aging. Although the cause and effect relation remains arguable, aging is associated with significant changes in diverse signaling events, characterized by enhanced or diminished responses of specific signaling pathways. In this review we will discuss how HNE may contribute to aging-related alterations of signaling pathways.

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