| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5501653 | Free Radical Biology and Medicine | 2017 | 67 Pages |
Abstract
We conclude suggesting that targeting HNE-driven cellular processes may represent a new more efficacious therapeutical intervention.
Keywords
MPTPNADPHGSHOXPHOS6-HydroxydopamineLPOiNOSDATeNOSα-SynACCPGC-1αHNEDDAHALDH2VMAT2mHTTHNAnicotinamide adenine dinucleotide phosphate hydrogenmitochondrial aldehyde dehydrogenase 26-OHDAADMAPFC1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine3,4-dihydroxyphenylacetaldehyde4-hydroxy-2-nonenalddCdopa decarboxylaseHO•O2•−ROSα-synucleinHydrogen peroxideAdenosine TriphosphateATPAlda-1bipolar disorderBipolar disordersneuropsychiatric disordersSchizophreniaPUFADepressionDopamine transporterHuntington's diseaseParkinson's diseasetyrosine hydroxylaseDopamineDimethylarginine dimethylaminohydrolaseasymmetric dimethylargininesuperoxide radicalHydroxyl radicalSODBBBinducible nitric oxide synthaseendothelial nitric oxide synthaseSuperoxide dismutaseUbiquitin-proteasome systemDOPALMitochondrial oxidative phosphorylationprefrontal cortexfrontal cortexanterior cingulate cortexLUHMESBlood-brain barriervesicular monoamine transporter 2Nitric oxideH2O2Lipid peroxidationGlutathioneReactive oxygen speciesUPS
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Authors
Adele Romano, Gaetano Serviddio, Silvio Calcagnini, Rosanna Villani, Anna Maria Giudetti, Tommaso Cassano, Silvana Gaetani,