| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5501655 | Free Radical Biology and Medicine | 2017 | 20 Pages |
Abstract
This review summarizes current knowledge on the formation of HNE-modified proteins, their fate in mammalian cells and their potential role as a damaging agents during oxidative stress. Furthermore, the potential of HNE-modified proteins as biomarkers for several diseases are highlighted.
Keywords
PARPGSTADHGAPDHHSP90PDIhsp70ADPPKCHNECysTHRCYP2E1FABPTropomyosin 1DHNHNA1,4-dihydroxynoneneAdenine dinucleotideADPRTALDH4-hydroxynonenalGSHTRPV1AcLDLATP synthaseNOxROSArgininealdehyde dehydrogenaseArgPoly-unsaturated fatty acidPUFAAlcohol dehydrogenaseNADPH oxidaseATPaseAlzheimer's diseaseParkinson's diseasethreonineHISCysteineMass spectrometryLysineLYSacetylated low density lipoproteinlow density lipoproteinLDLPROhistidineProteasomeProteolysisFatty acid binding proteinprotein disulfide isomeraseheat shock protein 70Heat shock protein 90Protein kinase CProlinepoly-ADP ribose polymeraseHELtransient receptor potential cation channel subfamily V member 1Glutathioneglutathione-S-transferaseglyceraldehyde-3-phosphate dehydrogenaseReactive oxygen speciesUPS
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Authors
José Pedro Castro, Tobias Jung, Tilman Grune, Werner Siems,