| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5501662 | Free Radical Biology and Medicine | 2017 | 35 Pages |
Abstract
Generation of oxidants by NOX follows a Gaussian distribution in the general population, where both extremes of the bell-shaped curve are considered to promote neurodegenerative diseases. Too little NOX2 activity promotes autoimmune neurodegeneration while too much NOX2 activity promotes microglia-dependent neurodegenerative mechanisms. The arrows represent potential therapeutic approaches to reach normal redox function in the CNS.218
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Authors
Silvia Sorce, Roland Stocker, Tamara Seredenina, Rikard Holmdahl, Adriano Aguzzi, Adriano Chio, Antoine Depaulis, Freddy Heitz, Peter Olofsson, Tomas Olsson, Venceslas Duveau, Despina Sanoudou, Sara Skosgater, Antonia Vlahou, Dominique Wasquel,