Rifampicin-induced injury in HepG2 cells is alleviated by TUDCA via increasing bile acid transporters expression and enhancing the Nrf2-mediated adaptive response

Article ID	Journal	Published Year	Pages	File Type
5501667	Free Radical Biology and Medicine	2017	34 Pages	PDF

Abstract

TUDCA alleviates RFP-induced injury in HepG2 cells by enhancing bile acid transporters expression and the Nrf2-mediated adaptive response, inhibiting the PERK-ATF4-CHOP pathway mediated apoptotic response.188

Keywords

ALF UPR Mrp2 ALT SOD1 γ-GT GSH SOD2 Nrf2 TUDCA GRP78 TBA CAT BSEP MDR1 MDA Ntcp GPx1 PXR 4-PBA TBIL DBil OATPs INH ATF4 RFP IBIL BAs C/EBP-homologous protein DMSO PKR-like ER kinase Small interfering RNA ROS siRNA Adenosine Triphosphate ATP AST Aspartate aminotransferase Drug-induced liver injury Alanine aminotransferase Alkaline phosphatase Tauroursodeoxycholic acid Bile acids isoniazid indirect bilirubin Direct bilirubin Tuberculosis ELISA Enzyme-linked immunosorbent assay CHOP AKP Bile acid transporters DILI Dimethyl sulfoxide Rifampicin SOD Sodium 4-phenylbutyrate HepG2 cells superoxide dismutase 1 Superoxide dismutase Superoxide dismutase 2 endoplasmic reticulum nuclear factor erythroid 2-related factor activating transcription factor 4 lactate dehydrogenase LDH malondialdehyde Acute liver failure Adaptive response glucose-regulated protein 78 multidrug resistance-associated protein 2 multidrug resistance protein 1 PERK Bile salt export pump Catalase total bile acid total bilirubin Glutathione glutathione peroxidase 1 Reactive oxygen species Pregnane X receptor

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Rifampicin-induced injury in HepG2 cells is alleviated by TUDCA via increasing bile acid transporters expression and enhancing the Nrf2-mediated adaptive response

Authors

Weiping Zhang, Lihong Chen, Hui Feng, Wei Wang, Yi Cai, Fen Qi, Xiaofang Tao, Jun Liu, Yujun Shen, Xiaofei Ren, Xi Chen, Jianming Xu, Yuxian Shen,