Melatonin-mediated upregulation of Sirt3 attenuates sodium fluoride-induced hepatotoxicity by activating the MT1-PI3K/AKT-PGC-1Î± signaling pathway

Article ID	Journal	Published Year	Pages	File Type
5501714	Free Radical Biology and Medicine	2017	65 Pages	PDF

Keywords

AMPK NOX4 Sirt3 SOD2 NRF1 PGC-1α DLR Jnk1 MT1 FOXO3a MT2 ALT NaF melatonin receptor 1A Bcl-2 GAPDH c-Jun N-terminal kinase 1 p53 GSH ERRα Sirtuin 3 COXIV MDA B-cell CLL/lymphoma 2 MAPKs NADPH oxidase 4 O2•−PI3K/AKT RAC-alpha serine/threonine-protein kinase ROS chromatin immunoprecipitation assay Electrophoretic mobility shift assay AST Aspartate aminotransferase Alanine aminotransferase Akt Bax forkhead box O3 Sodium Tumor suppressor p53 Hepatotoxicity EMSA یا electrophoretic mobility shift assay Superoxide manganese superoxide dismutase cytochrome c oxidase subunit IV Nuclear respiratory factor 1 Sodium fluoride malondialdehyde Melatonin peroxisome proliferator-activated receptor gamma coactivator 1α BCL2-associated X protein adenosine monophosphate-activated protein kinase CHiP mitogen-activated protein kinases Glutathione glyceraldehyde-3-phosphate dehydrogenase Reactive oxygen species Estrogen-related receptor alpha

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Melatonin-mediated upregulation of Sirt3 attenuates sodium fluoride-induced hepatotoxicity by activating the MT1-PI3K/AKT-PGC-1Î± signaling pathway

Authors

Chao Song, Jiamin Zhao, Beibei Fu, Dan Li, Tingchao Mao, Wei Peng, Haibo Wu, Yong Zhang,