6-Hydroxy-5,7-dimethoxy-flavone suppresses the neutrophil respiratory burst via selective PDE4 inhibition to ameliorate acute lung injury

Article ID	Journal	Published Year	Pages	File Type
5501795	Free Radical Biology and Medicine	2017	14 Pages	PDF

Keywords

pKa Cytochalasin B fMLF ARDS FPR N-formyl-l-methionyl-l-leucyl-l-phenylalanine GPCR PDE PGE NADPH cAMP MPO PMA O2•−Cyclic adenosine monophosphate adenylate cyclase Acute lung injury superoxide anion Akt Ali Chronic obstructive pulmonary disease COPD Acute respiratory distress syndrome phorbol myristate acetate Phosphodiesterase lactate dehydrogenase LDH myeloperoxidase nicotinamide adenosine dinucleotide phosphate protein kinase A protein kinase B prostaglandin E formyl peptide receptor G protein-coupled receptor

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6-Hydroxy-5,7-dimethoxy-flavone suppresses the neutrophil respiratory burst via selective PDE4 inhibition to ameliorate acute lung injury

Authors

Yung-Fong Tsai, Tzu-Chi Chu, Wen-Yi Chang, Yang-Chang Wu, Fang-Rong Chang, Shun-Chin Yang, Tung-Ying Wu, Yu-Ming Hsu, Chun-Yu Chen, Shih-Hsin Chang, Tsong-Long Hwang,