Lack of mitochondrial DNA impairs chemical hypoxia-induced autophagy in liver tumor cells through ROS-AMPK-ULK1 signaling dysregulation independently of HIF-1Î±

Article ID	Journal	Published Year	Pages	File Type
5501839	Free Radical Biology and Medicine	2016	42 Pages	PDF

Keywords

PDK1 LC3 GLUT1 AMPK BNIP3 3MA SOD2 CoCl2 PGK1 Cyclin D1 CFSE p27 P21 CCND1 ULK1 HPRT1 hypoxanthine phosphoribosyltransferase-1 GRP-78 AVOs BNIP3L Cyclin-dependent kinase inhibitor 1B BCL2/adenovirus E1B 19 kDa interacting protein 3 unc-51-like kinase 1 ERK DFO mTOR Deferoxamine VEGFA PI3K DCFH-DA HIF-1α 2′,7′-dichlorofluorescein diacetate 3-methyladenine AMP-activated protein kinase C/EBP homologous protein HCC ROS Akt Autophagy Acidic vesicular organelles CHOP mtDNA endoplasmic reticulum hypoxia inducible factor-1α Vascular endothelial growth factor A Phosphoglycerate kinase 1 phosphoinositide 3-kinase lactate dehydrogenase LDH Retrograde regulation cyclin-dependent kinase inhibitor 1A Mitochondria mammalian target of rapamycin Hepatocarcinoma glucose-regulated protein 78 microtubule-associated protein 1A/1B-light chain 3 protein kinase B Pyruvate dehydrogenase kinase 1 Chloroquine Cobalt chloride extracellular regulated kinase glucose transporter 1 Reactive oxygen species

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Lack of mitochondrial DNA impairs chemical hypoxia-induced autophagy in liver tumor cells through ROS-AMPK-ULK1 signaling dysregulation independently of HIF-1Î±

Authors

Jose J.G. Marin, Elisa Lozano, Maria J. Perez,