ROS-JNK1/2-dependent activation of autophagy is required for the induction of anti-inflammatory effect of dihydroartemisinin in liver fibrosis

Article ID	Journal	Published Year	Pages	File Type
5501853	Free Radical Biology and Medicine	2016	12 Pages	PDF

Keywords

NACHT, LRR and PYD domains-containing protein 3 GSSG IFN-γ NAC GSH ATG LC3 CAT ALT NLRP3 Jnk HSCs dihydroartemisinin α-SMA c-Jun N-terminal kinase ERK1/2 MAPK Mitogen activated protein kinases N-acetylcysteine ROS AST Aspartate aminotransferase Alanine aminotransferase alpha smooth muscle actin ALP Alkaline phosphatase Autophagy inflammation Tem interferon-γ interleukin tumor necrosis factor α DHA Hepatic stellate cells TNF-α Liver fibrosis Transmission electron microscopy microtubule-associated protein 1 light chain 3 autophagy-related gene Catalase Glutathione glutathione disulfide Reactive oxygen species

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ROS-JNK1/2-dependent activation of autophagy is required for the induction of anti-inflammatory effect of dihydroartemisinin in liver fibrosis

Authors

Zili Zhang, Mei Guo, Shifeng Zhao, Jiangjuan Shao, Shizhong Zheng,