Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5501890 | Free Radical Biology and Medicine | 2017 | 62 Pages |
Abstract
The actin cytoskeleton is critical for form and function of vascular cells, serving mechanical, organizational and signaling roles. Because many cytoskeletal proteins are sensitive to reactive oxygen species, redox regulation has emerged as a pivotal modulator of the actin cytoskeleton and its associated proteins. Here, we summarize work implicating oxidants in altering actin cytoskeletal proteins and focus on how these alterations affect cell migration, proliferation and contraction of vascular cells. Finally, we discuss the role of oxidative modification of the actin cytoskeleton in vivo and highlight its importance for vascular diseases.
Keywords
ECMNF-κBPAObFGFGSHNACGPXFAKF-actinWASPGSSGCysRNSSRFCaMKIIGPCRsAP-1PLCPKCIP3RPAKPKGPDGFNCXSNOMRTF-ATAZMLCPVSMCsG-actinMLCKLTCCS-nitrosylationGEFstranscriptional co-activator with PDZ-binding motifCSKONOO-Myocardin-related transcription factorGDISLMW-PTPDiacyglycerolmolecule interacting with CasL•NO2filamentous actinglobular actinG-protein-coupled receptorsHO•MAPKN-acetyl-cysteineNADPH oxidasesO2•−PTPsROSRTKsHydrogen peroxideAlphaSulfenic acidSulfonic acidSulfinic acidPhenylarsine oxideYAPBETAVascular diseaseHic-5Hydroxyl radicalSarcoplasmic reticulumDAGRho kinaseMyosin heavy chainmyosin light chain kinaseCAMSODVascular smooth muscle cellsSuperoxideSuperoxide dismutaseactin cytoskeletonCysteineGapsGuanine nucleotide exchange factorsNon-muscle myosin IIVascular endothelial growth factorVascular Endothelial Growth Factor (VEGF)platelet-derived growth factorbasic fibroblast growth factornuclear factor-κBserum response factorMyosin light chain phosphatasephospholipase CSERCAExtracellular matrixSodium-calcium exchangerMethionineMHCRedox regulationMETNitrogen dioxideNitric oxideH2O2calmodulin-dependent protein kinase IIprotein tyrosine phosphatasesWiskott–Aldrich syndrome proteinGTPase activating proteinsactivator protein-1yes-associated proteinprotein kinase GProtein kinase Cmitogen-activated protein kinasePeroxynitriteDisulfide bondCalmodulinp21-activated kinasefocal adhesion kinaseGammaGlutathioneglutathione disulfideglutathione peroxidasereactive nitrogen speciesReactive oxygen speciesInositol 1,4,5-trisphosphate receptorreceptor tyrosine kinasesRock
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Authors
Qian Xu, Lauren P. Huff, Masakazu Fujii, Kathy K. Griendling,