Reactive oxygen species and cancer paradox: To promote or to suppress?

Article ID	Journal	Published Year	Pages	File Type
5501951	Free Radical Biology and Medicine	2017	21 Pages	PDF

Keywords

ECM ABC AMPK CSC LKB1 NF-κB PI3K MMP TGF-β1 Jnk BHT tPA Nrf2 NADPH GSH NAC EGCG GPX mTOR COX-2 FAK Mcl-1 Bcl-2 RSL ANT PTP RNS MPTP AP-1 HIF-1α GAG ATG PKC APAf-1 cyt-c DISC FasR BNIP3 Drp1 BSO SMase VDAC Cytochrome-c PDGF HDAC1 ASK1 VHL Trx TrxR Dnmt1 HGF uPA CDKN2A CDX1 c-FLIP TNFR cellular FLICE-inhibitory protein P-gp RUNX3 HSPB1 RIP1 DNA methyltransferase 1 PRX GRx SQSTM1 sequestosome 1 TSC2 PTP1B Ref-1 cyclin dependent kinase inhibitor 2A Redox factor-1 DUOX1 PGAM5 GLUD1 glutamate dehydrogenase 1 PYGL second mitochondria-derived activator of caspase/direct inhibitor of apoptosis-binding protein with low pI tetradecanoyl phorbol acetate Xanthine oxidase AMP-activated protein kinase ataxia-telangiectasia mutated keap1 PAR-4 C/EBP homologous protein c-Jun N-terminal kinase ERK1/2 MAPK N-acetylcysteine NOx O2•−P-glycoprotein PKB/AKT ROS Hydrogen peroxide Angiogenesis superoxide anion AIF Autophagy Von Hippel–Lindau Smac/DIABLO sphingomyelinase mitochondrial permeability transition pore epigallocatechin gallate NADPH oxidase LOX Molecular oxygen Bax transforming growth factor beta 1 adenine nucleotide translocase thioredoxin reductase tumor necrosis factor-α CHOP thioredoxin Apoptosis ATM dual oxidase 1 Hydroxyl radical retinoblastoma Riboflavin kinase TIMP electron transport chain SOD breast cancer 1 Endothelial cells Cancer stem cells Superoxide dismutase Cyclooxygenase-2 endoplasmic reticulum apoptosis-inducing factor hypoxia-inducible factor-1α Hepatocyte growth factor Nuclear factor erythroid 2–related factor 2 phosphoglycerate mutase family member 5 Fas Ligand FasL Vascular endothelial growth factor Vascular Endothelial Growth Factor (VEGF)TNF-α nuclear factor-κB Ferroptosis phosphatase and tensin homolog Phosphotyrosine phosphatase phosphoinositide 3-kinase urokinase plasminogen activator TRAIL B-cell lymphoma-2 Myeloid cell leukemia 1 lipoxygenase TNF-related apoptosis-inducing ligand Extracellular matrix matrix metalloproteinase Metastasis Tissue inhibitor of metalloproteinase Necroptosis nicotinamide adenine dinucleotide phosphate mammalian target of rapamycin H2O2 butylated hydroxytoluene histone deacetylase 1 ETc prostate apoptosis response-4 Bcl-2-associated X protein Protein tyrosine phosphatase 1B activator protein 1 Kelch-like ECH-associated protein 1 dynamin-related protein 1 receptor-interacting protein kinase 1 protein kinase B Protein kinase C mitogen activated protein kinase Peroxiredoxin tuberous sclerosis complex 2 death-inducing signaling complex BRCA1 Pten autophagy-related gene voltage-dependent anion-selective channel ATP-binding cassette extracellular signal-regulated kinase 1/2 apoptosis signal-regulating kinase 1 focal adhesion kinase liver kinase B1 Glutathione glutathione reductase glutathione peroxidase Glutaredoxin Glul Glycosaminoglycan Glycogen phosphorylase reactive nitrogen species Reactive oxygen species Fas receptor TNF receptor death receptor •OH

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Reactive oxygen species and cancer paradox: To promote or to suppress?

Authors

Sehamuddin Galadari, Anees Rahman, Siraj Pallichankandy, Faisal Thayyullathil,