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CQ synergistically sensitizes human colorectal cancer cells to SN-38/CPT-11 through lysosomal and mitochondrial apoptotic pathway via p53-ROS cross-talk

Article ID Journal Published Year Pages File Type
5501971 Free Radical Biology and Medicine 2017 54 Pages PDF
Keywords
NAC∆ψmPepstatin ASN-383-MAN-acetyl-l-cysteineLMPp533-methyladenineDMSOSmall interfering RNAROSsiRNAAcridine orangeApoptosisDimethyl sulfoxideColorectal cancercombination indexvitamin CMitochondrial membrane potentialCathepsin Bcathepsin DCRCChloroquineReactive oxygen species
Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Ageing
Preview
CQ synergistically sensitizes human colorectal cancer cells to SN-38/CPT-11 through lysosomal and mitochondrial apoptotic pathway via p53-ROS cross-talk
Authors
Pinjia Chen, Xiaoyong Luo, Peipei Nie, Baoyan Wu, Wei Xu, Xinpeng Shi, Haocai Chang, Bing Li, Xiurong Yu, Zhengzhi Zou,
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Journal
Free Radical Biology and Medicine
Journal: Free Radical Biology and Medicine
Related Categories
NAC
∆ψm
Pepstatin A
SN-38
3-MA
N-acetyl-l-cysteine
LMP
p53
3-methyladenine
DMSO
Small interfering RNA
ROS
siRNA
Acridine orange
Apoptosis
Dimethyl sulfoxide
Colorectal cancer
combination index
vitamin C
Mitochondrial membrane potential
Cathepsin B
cathepsin D
CRC
Chloroquine
Reactive oxygen species
Ageing
Biochemistry
Biochemistry, Genetics and Molecular Biology (General)
Biophysics
Biotechnology
Cancer Research
Cell Biology
Clinical Biochemistry
Developmental Biology
Endocrinology
Genetics
Molecular Biology
Molecular Medicine
Physiology
Structural Biology
Related Journals
Neurobiology of Aging
Revista Española de Geriatría y Gerontología
Ageing Research Reviews
Archives of Gerontology and Geriatrics
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
Experimental Gerontology
Journal of Geriatric Oncology
Journal of the Neurological Sciences
Maturitas
Mechanisms of Ageing and Development
Parkinsonism & Related Disorders
Redox Biology
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