Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5502598 | Journal of the Neurological Sciences | 2017 | 7 Pages |
Abstract
Although naftopidil was developed as an alpha-1 adrenoceptor antagonist, our previous spinal cord slice experiments showed that the activation of an alpha-1 adrenoceptor in substantia gelatinosa increases the frequency of mIPSCs. This result suggested that, under our conditions, naftopidil may interact with a receptor(s) other than an alpha-1 adrenoceptor in the spinal dorsal horn. The present results suggested that naftopidil enhances the release of GABA and glycine by activating inhibitory interneuron terminals in the spinal dorsal horn via a receptor other than an alpha-1 adrenoceptor, thereby modulating sensory transmission in the substantia gelatinosa.
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Authors
Daisuke Uta, Du-Jie Xie, Tsuyoshi Hattori, Ken-ichi Kasahara, Megumu Yoshimura,