Decreased baroreflex sensitivity in Parkinson's disease is associated with orthostatic hypotension

BRS was significantly lower in the PD group, supine hypertension and orthostatic hypotension was strongly associated with low BRS. We determined for the first time that orthostatic hypotension strongly correlates with decreased baroreflex sensitivity in PD patients. Moreover, orthostatic hypotension was associated with low BRS not only qualitatively but also quantitatively. We also revealed a strong association between LDOPA + COMTI therapy and decreased BRS in the literature for the first time.