Kynurenic acid and its analogue can alter the opioid receptor G-protein signaling after acute treatment via NMDA receptor in rat cortex and striatum

Article ID	Journal	Published Year	Pages	File Type
5502877	Journal of the Neurological Sciences	2017	8 Pages	PDF

Abstract

We previously demonstrated that KYNA1 and KYNA acutely altered opioid receptor function in vivo and in vitro through the NMDA receptor depending on the opioid receptor type and brain region. This study may lead to a new, indirect approach to influence opioid receptor signaling.

Keywords

GTP MOPr DopR EGTA GTPγS MK-801 GPCR S.E.M.3-nitro-l-tyrosine DAMGO G-protein coupled receptor [35S]GTPγS binding ethylene glycol tetraacetic acid kynurenic acid Tem Tris-HCl GDP standard error of means CNS BBB central nerve system Blood-brain barrier Cerebrospinal fluid CSF G-protein KYNA guanosine 5′-triphosphate guanosine 5′-diphosphate Opioid receptor

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Kynurenic acid and its analogue can alter the opioid receptor G-protein signaling after acute treatment via NMDA receptor in rat cortex and striatum

Authors

Reza Samavati, Ferenc Zádor, Edina SzÅ±cs, Bernadett Tuka, Diána Martos, Gábor Veres, Róbert Gáspár, István M. Mándity, Ferenc Fülöp, László Vécsei, Sándor Benyhe, Anna Borsodi,