Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5503142 | Journal of the Neurological Sciences | 2016 | 20 Pages |
Abstract
Our results confirm that subclinical to overt cardiovascular autonomic failure may occur from the early stages of PD. The less efficient adaptive response to physical stimuli during the CPET and postural changes observed in untreated PD patients possibly reflect cardiac sympathetic denervation, although the involvement of PD-related motor impairment in physical deconditioning cannot be excluded.
Keywords
CPETH/MFEV1UPDRSBRSFVCHRVWorkloadParkinson's diseaseCardiopulmonary exercise testMaximal oxygen consumptionBaroreflex sensitivitytwo-dimensionalmetaiodobenzylguanidineHeart rateforced vital capacityNon-motor symptomsMIBGBlood pressureUnified Parkinson's Disease Rating Scaleheart rate variabilityOrthostatic hypotensionnormalized unitsCOMPASS
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Authors
Stefano Strano, Alessandra Fanciulli, Massimiliano Rizzo, Paolo Marinelli, Paolo Palange, Dorina Tiple, Giuseppe De Vincentis, Giovanni Calcagnini, Federica Censi, Giuseppe Meco, Carlo Colosimo,