| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5503251 | Journal of the Neurological Sciences | 2017 | 18 Pages |
Abstract
- Serotonin and norepinephrine transporters are capable of dopamine reuptake in the parkinsonian striatum.
- Duloxetine is a serotonin and norepinephrine reuptake inhibitor.
- We investigated effects of duloxetine in patients with advanced Parkinson's disease.
- Adjunctive duloxetine treatment improved motor symptoms and reduced daily OFF-time in some patients.
- Duloxetine treatment might have beneficial treatment effects for mood and motor symptoms in Parkinson's disease.
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Authors
Haruo Nishijima, Tatsuya Ueno, Tomoya Kon, Rie Haga, Yukihisa Funamizu, Akira Arai, Chieko Suzuki, Jin-ichi Nunomura, Masayuki Baba, Masahiko Tomiyama,