Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5503603 | Mechanisms of Ageing and Development | 2017 | 25 Pages |
Abstract
The telomere protects against genomic instability by minimizing the accelerated end resection of the genetic material, a phenomenon that results in severe chromosome instability that could favor the transformation of a cell by enabling the emergence of tumor-promoting mutations. Some mechanisms that avoid this fate, such as capping and loop formation, have been very well characterized; however, telomeric non-coding transcripts, such as long non-coding RNAs (lncRNAs), should also be considered in this context because they play roles in the organization of telomere dynamics, involving processes such as replication, degradation, extension, and heterochromatin stabilization. Although the mechanism through which the expression of telomeric transcripts regulates telomere dynamics is not yet clear, a non-coding RNA component opens the research options in telomere biology and the impact that it can have on telomere-associated diseases such as cancer.
Keywords
POT1EST1GAR domainheterogeneous nuclear ribonucleoprotein A1hnRNPA1ICF syndromeTERRAHP1CTCFRAP1TIN2RPAlncRNATPP1TSSATRXALTORCTPETelomere position effectTarreplication protein ATelomereTelomeraseprotection of telomeres 1transcription start siteAlternative lengthening of telomeresheterochromatin protein 1origin recognition complexChromatin
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Diego Oliva-Rico, Luis A. Herrera,