Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5503674 | Mechanisms of Ageing and Development | 2017 | 35 Pages |
Abstract
The target of rapamycin (TOR) pathway integrates signals from extracellular and intracellular agents, such as growth factors, nutrients, mediators of energy balance, oxygen availability and other environmental cues. It allows the regulation of multiple cellular processes including protein and lipid synthesis, ribosome biogenesis, autophagy and metabolic processes. Being conserved across different phyla, TOR regulates longevity of various organisms in response to dietary conditions. In this review we described the main components of the TOR pathway and its upstream effectors and downstream processes in relation to aging. The potential contribution of the TOR pathway in lifespan-extending effects of varied dietary interventions, and the anti-aging drugs rapamycin and metformin direct or indirect regulation of TOR activity in yeasts, worms, flies and mammals are also discussed.
Keywords
PDCD4hypoxia inducible factor αRHEBS6KYY14EBPHIF1α4E binding proteinAMPKTSCSirt1PI3KTNFαTORIGFS6 kinaseNutritionsilent information regulator 1tumor necrosis factor αRapamycinRaptorAgingLifespanInsulin-like growth factorphosphatidylinositol-3-kinasedietary restrictionprogrammed cell death 4target of rapamycinRas homologue enriched in brainregulatory-associated protein of mTORadenosine monophosphate-activated protein kinaseTuberous sclerosis complexDEPTOR
Related Topics
Life Sciences
Biochemistry, Genetics and Molecular Biology
Ageing
Authors
Oleh Lushchak, Olha Strilbytska, Veronika Piskovatska, Kenneth B. Storey, Alexander Koliada, Alexander Vaiserman,