Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5517772 | International Journal of Medical Microbiology | 2016 | 5 Pages |
Abstract
Clonal variants of Mycobacterium tuberculosis (MTB) coexist in specific patients, although the dynamics of their emergence is unknown. We used MIRU-VNTR to detect microevolution leading to variants of MTB in 3 out of 19 patients (15%) soon after diagnosis (61-85Â days). Most harbored SNPs and for some of them a potential functional role was suggested. Microevolution in tuberculosis seems to occur sooner and more often than expected and could affect tracking of transmission.
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Authors
Laura Pérez-Lago, Ana Isabel RodrÃguez Borlado, Iñaki Comas, Marta Herranz, MarÃa Jesús Ruiz-Serrano, Emilio Bouza, DarÃo GarcÃa-de-Viedma,