Is rs763780 in IL-17F gene considered risk factor to multiple sclerosis in Egyptian patients?

Despite major efforts by the scientific community over the years, our understanding of the pathogenesis or the mechanisms of injury of multiple sclerosis is still limited. Multiple lines of evidence implicate that T cells play a central role in both mediating and regulating MS pathophysiology, and efforts to develop rational therapeutic strategies for MS have focused on understanding factors which control T cell function. So, aim of this study is to determine the association between the polymorphic features located within the IL-17F gene and susceptibility to MS in Egyptian patients. In this study, single nucleotide polymorphism (SNP) (rs763780; T7488C; His161Arg) of IL-17 F gene was genotyped in 178 Egyptians divided into 83 MS patients and 95 healthy controls with matched age and sex by using Genotyping Taqman assay. All genotypic and allelic frequencies of the tested IL-17 F polymorphism were in Hardy-Weinberg equilibrium. A significantly increased frequency of rs763780 CT + CC genotypes (p = 0.009, odds ratio = 2.56 (95% CI: 1.4-4.7) and C allele (P = 0.005, odds ratio = 2.05 (95% CI: 1.24-3.39) was detected in MS patients compared to controls. Additionally, we elucidated a significantly high risk for susceptibility of the disease incidence in female cohort only (P = 0.006, odds ratio = 3.3 (95% CI: 1.53-7.12).IL-17 F CT genotype and C allele may be associated with a susceptibility to MS by a gender-dependent mechanism that contributes to unique predisposition in females. So this rs763780 can be considered risk factor for the development of MS in Egyptian population.