Ac2-26 peptide and serine protease of Bothrops atrox similarly induces angiogenesis without triggering local and systemic inflammation in a murine model of dorsal skinfold chamber

•The dorsal skin chamber is a versatile tool to observe the angiogenic process.•Ac2-26 peptide from annexin A1 protein and serine protease of Bothrops atrox promote new blood vessels formation.•These mediators do not induce inflammatory cells recruitment and changes in cytokines levels.