Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5520103 | Advanced Drug Delivery Reviews | 2016 | 17 Pages |
Abstract
Nucleic acid sequence variations have been implicated in many diseases, and reliable detection and quantitation of DNA/RNA biomarkers can inform effective therapeutic action, enabling precision medicine. Nucleic acid analysis technologies being translated into the clinic can broadly be classified into hybridization, PCR, and sequencing, as well as their combinations. Here we review the molecular mechanisms of popular commercial assays, and their progress in translation into in vitro diagnostics.
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Authors
Dmitriy Khodakov, Chunyan Wang, David Yu Zhang,