Article ID Journal Published Year Pages File Type
5520103 Advanced Drug Delivery Reviews 2016 17 Pages PDF
Abstract

Nucleic acid sequence variations have been implicated in many diseases, and reliable detection and quantitation of DNA/RNA biomarkers can inform effective therapeutic action, enabling precision medicine. Nucleic acid analysis technologies being translated into the clinic can broadly be classified into hybridization, PCR, and sequencing, as well as their combinations. Here we review the molecular mechanisms of popular commercial assays, and their progress in translation into in vitro diagnostics.

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Related Topics
Life Sciences Biochemistry, Genetics and Molecular Biology Biotechnology
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