| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5521276 | Drug Discovery Today: Technologies | 2016 | 7 Pages |
Abstract
Cerebral open flow microperfusion (cOFM) is a new in-vivo technique for continuous sampling of the interstitial fluid in brain tissue. cOFM can be used to monitor substance transport across the blood-brain barrier (pharmacokinetics) and to investigate metabolic changes in brain tissue after drug application (pharmacodynamics). The possibility of long-term implantation into the brain makes cOFM an outstanding tool in the development of brain relevant pharmaceutics.
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Authors
Thomas Birngruber, Frank Sinner,