| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5521292 | Drug Discovery Today: Technologies | 2016 | 6 Pages |
Abstract
Epigenetic control of gene expression is enforced in part through histone modifications. Bromodomain and extra terminal domain (BET) proteins function as crucial chromatin readers, responsible for interpretation of the chromatin code in diverse cellular contexts, ultimately impacting gene transcription. BET proteins can play a major role in inflammation by profoundly affecting the biology of the Thelper 17 (TH17) lineage. We summarize recent studies focusing on BET inhibition as a viable therapeutic alternative for the control of autoimmune diseases driven by aberrant activation of TH17 cells.
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Authors
Srimoyee Ghosh, Jose M. Lora,