Andrographolide-loaded nanoparticles for brain delivery: Formulation, characterisation and in vitro permeability using hCMEC/D3 cell line

Article ID	Journal	Published Year	Pages	File Type
5521382	European Journal of Pharmaceutics and Biopharmaceutics	2017	40 Pages	PDF

Keywords

rHb ULOQ QCL NaCl PSA WS2 EtOH EMA HSA PDI adsorptive-mediated transcytosis logP TFA MRM WSS Tween 80 LRP1 QCs hCMEC/D3 LLOQ QCH DLS PBS ESI FDA ECA BSA DMSO UPLC-MS/MS ζ Potential human serum albumin bovine serum albumin European Medicines agency Ethanol internal standard Trifluoroacetic acid Formic acid Andrographolide Tem Encapsulation efficiency upper limit of quantification lower limit of quantification ATM CNS Dimethyl sulfoxide Food and Drug Administration Hour BBB Sodium chloride central nervous system polydispersity index apparent permeability coefficient ultra-performance liquid chromatography tandem mass spectrometry Loading capacity Blood-brain barrier Permeability-surface area product Phosphate-buffered saline Polar surface area QCM Transmission electron microscopy multiple reaction monitoring Papp Zeta potential Dynamic Light Scattering Low density lipoprotein receptor-related protein 1 quality controls

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Andrographolide-loaded nanoparticles for brain delivery: Formulation, characterisation and in vitro permeability using hCMEC/D3 cell line

Authors

Clizia Guccione, Mouhssin Oufir, Vieri Piazzini, Daniela Elisabeth Eigenmann, Evelyn Andrea Jähne, Volha Zabela, Maria Teresa Faleschini, Maria Camilla Bergonzi, Martin Smiesko, Matthias Hamburger, Anna Rita Bilia,