| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5522882 | Synthetic and Systems Biotechnology | 2016 | 8 Pages |
Abstract
Two potent anti-MRSA tanshinone glycosides (1 and 2) were discovered by targeted microbial biotransformation, along with rapid identification via MS/MS networking. Serial reactions including dehydrogenation, demethylations, reduction, glycosylation and methylation have been observed after incubation of tanshinone IIA and fungus Mucor rouxianus AS 3.3447. In addition, tanshinosides B (2) showed potent activities against serial clinical isolates of oxacillin-resistant Staphylococcus aureus with MIC values of 0.78 μg/mL. This is the first study that shows a significant increase in the level and activities of tanshinone glycosides relative to the substrate tanshinone IIA.
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Authors
Wenni He, Miaomiao Liu, Pei Huang, Wael M. Abdel-Mageed, Jianying Han, Jeramie D. Watrous, Don D. Nguyen, Wenzhao Wang, Fuhang Song, Huanqin Dai, Jingyu Zhang, Ronald J. Quinn, Tanja Grkovi, Houwei Luo, Lixin Zhang, Xueting Liu,