Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5524318 | Biology of Blood and Marrow Transplantation | 2016 | 9 Pages |
â¢Outcomes for both unrelated bone marrow transplantation and unrelated cord blood transplantation are currently not statistically inferior to those of identical related bone marrow transplantationâ¢Unrelated cord blood transplantation is useful option for patients with clinical urgent situationsâ¢New strategies are needed to reduce early transplantation-related mortality after unrelated cord blood transplantation
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains the best therapeutic option for childhood high-risk acute leukemia. However, which donor source is optimal for children lacking an identical sibling remains unclear. To evaluate the clinical impact of donor source on allo-HSCT in childhood acute leukemia, we analyzed data from 577 children who underwent allo-HSCT after a myeloablative regimen during first or second complete remission from 2005 to 2012, using registry data of the Japan Society for Hematopoietic Cell Transplantation, and we compared outcomes of 7/8 to 8/8 HLA allelic-matched unrelated bone marrow transplantation (UR-BMT, nâ=â218) and 4/6 to 6/6 HLA allelic-matched unrelated cord blood transplantation (UR-CBT, nâ=â200) to those of HLA-identical related bone marrow transplantation (ID-BMT, nâ=â159). The median follow-up of survivors was 40.0 months. Three-year overall survival (OS) and leukemia-free survival (LFS) rates for ID-BMT, UR-BMT, and UR-CBT were 74.8% and 69.0%, 75.0% and 69.6%, and 71.8% and 63.8%, respectively. The multivariate analysis demonstrated that OS and LFS for the 3 groups are comparable, although UR-CBT carries a greater risk of nonrelapse mortality (hazard ratio, 2.20; Pâ=â.03, compared to ID-BMT) in the myeloablative setting for childhood high-risk acute leukemia.