| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5524679 | Blood Reviews | 2017 | 6 Pages |
Abstract
Recent comprehensive genetic studies revealed numerous genetic aberrations underlying a group of high-risk leukemias that share a specific activated kinase gene expression pattern. These ALLs were first recognized by the expression profile similar to that of Philadelphia chromosome-positive ALL and currently can be sub-classified by the main aberrantly activated kinase in the leukemic cells. We herein review the biological mechanisms and diagnostic and clinical challenges presented by these leukemias.
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Authors
Yishai Ofran, Shai Izraeli,