Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5525059 | Cancer Genetics | 2017 | 5 Pages |
â¢Two variants were associated with prognosis of lung cancer in never-smoking females.â¢TP63 rs7631358 Gâ>âA was associated with a relatively worse overall survival.â¢CSF1R rs10079250 Aâ>âG was associated with a relatively better disease-free survival.
A number of genome-wide association studies have reported several variants that influence the risk of lung cancer in never-smoking females. We evaluated the impact of these variants on survival outcome in never-smoking females with non-small cell lung cancer (NSCLC). In total, 510 never-smoking females with NSCLC who underwent curative surgery were enrolled. Eleven variants associated with lung cancer susceptibility in never-smoking females were genotyped and their associations with survival outcome were analyzed. Among these 11 variants, TP63 rs7631358 and CSF1R rs10079250 affected survival outcomes. TP63 rs7631358 Gâ>âA was associated with a relatively worse overall survival (under a dominant model; hazard ratioâ=â2.31, 95% confidence intervalâ=â1.18-4.52, Pâ=â0.01). CSF1R rs10079250 Aâ>âG was associated with a relatively better disease-free survival (under a codominant model; hazard ratioâ=â0.70, 95% confidence intervalâ=â0.53-0.93, Pâ=â0.01). These results suggest that TP63 rs7631358 Gâ>âA and CSF1R rs10079250 Aâ>âG may affect the prognosis of NSCLC in never-smoking females, as well as the risk of lung cancer.