| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5525583 | Cancer Letters | 2017 | 7 Pages |
â¢circRNA is exonic, intronic or retained-intronic.â¢CircRNAs mediate transcriptional and post-transcriptional regulation of gene and protein expression.â¢CircRNAs are critical for cancer biology.
Circular RNAs (circRNAs) are a type of non-coding RNA molecules that lack a 5â²-terminal cap and 3â²-terminal poly A tail. A large number of circRNAs have been identified through biological experiments, computational methods and high-throughput sequencing. CircRNA sequence composition determines if a given circRNA is exonic, intronic or retained-intronic. CircRNAs are more abundant and stable than linear mRNAs, and their expression is both step- and location-specific. CircRNAs mediate transcriptional and post-transcriptional regulation of gene and protein expression. CircRNAs regulate cancer development via multiple mechanisms, including miRNA sponges, modulating Wnt signaling pathway and epithelial-mesenchymal transition. An in-depth study of circRNA will provide a better understanding of carcinogenesis and assist in developing clinical diagnostic and therapeutic strategies.
