| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 55260 | Catalysis Today | 2013 | 7 Pages |
We present design, synthesis and application of basic chiral ionic liquids based on commercially available (S)-proline. This new set of chiral ionic liquids was specifically designed to replace trifluoroacetic acid in enamine-based organocatalysis for asymmetric CC bond formation. Based on their permanent charge, these chiral ionic liquids could be applied as organocatalysts in asymmetric aldol reaction of 4-nitrobenzaldehyde and acetone, and good yields and selectivities up to 80%ee could be obtained without additional acid.
Graphical abstractFigure optionsDownload full-size imageDownload high-quality image (116 K)Download as PowerPoint slideHighlights► Basic chiral ionic liquids. ► Acid-free asymmetric aldol reaction. ► Ionic liquids for organocatalysis.
