Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5526167 | European Journal of Cancer | 2017 | 8 Pages |
â¢The limitations of randomised clinical trials to evidence-based medicine are reviewed.â¢Complementary strategies based on exploiting population-based registries and electronic health records are discussed.â¢A novel approach combining population-based registry and electronic health record features is proposed.
Randomised clinical trials (RCTs) are considered the basis of evidence-based medicine. It is recognised more and more that application of RCT results in daily practice of clinical decision-making is limited because the RCT world does not correspond with the clinical real world. Recent strategies aiming at substitution of RCT databases by improved population-based registries (PBRs) or by improved electronic health record (EHR) systems to provide significant data for clinical science are discussed. A novel approach exemplified by the HemoBase haemato-oncology project is presented. In this approach, a PBR is combined with an advanced EHR, providing high-quality data for observational studies and support of best practice development. This PBRÂ +Â EHR approach opens a perspective on randomised registry trials.