Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5526397 | European Journal of Cancer | 2017 | 8 Pages |
â¢Long-term outcomes of adults with first-relapsed/refractory ALCL in the pre-brentuximab vedotin era are described.â¢Most adults with first-relapsed/refractory ALCL have poor outcomes.â¢Survival of ALK(+) and ALK(â) patients did not differ.
BackgroundLong-term outcomes of adults with first-relapsed/refractory (R/R) systemic anaplastic large-cell lymphoma (ALCL) are not definitively established and should be evaluated.Patients and methodsWe previously published the long-term outcomes of adults with ALCL initially treated with polychemotherapy in LYmphoma Study Association (LYSA) prospective clinical trials conducted during the pre-brentuximab vedotin era. Herein, we report the long-term outcomes of those patients after the first-relapsed/refractory (R/R) events.ResultsAmong the 138 (64 (anaplastic lymphoma kinase (ALK(+)) and 74 ALK(â) ALCL) adults initially treated in clinical trials, 40 (14 ALK(+) and 26 ALK(â)) first-R/R ALCL patients and their long-term outcomes were analysed. Median follow-up from the first-R/R events was 12.5 years. For ALK(+) and ALK(â) patients, respectively, median [range] findings were as follows: age at first-R/R event: 35 [19-76] and 61 [34-81] years; time between inclusion in first-line clinical trials and first-R/R events was 6 [1.5-34] and 11.1 [1-67] months (PÂ =Â 0.36); with median (95% confidence interval) progression-free survival after the first-R/R events: 3.8 (0.7-14.8) and 5.3 (2.4-8.4) months (PÂ =Â 0.39); and overall survival: 13.6 (0.7-89) and 8.1 (3.3-25) months (PÂ =Â 0.96). ALCL was the main cause of death.ConclusionMost adults with first-R/R ALCL have poor outcomes, with no significant differences between patients with ALK(+) or ALK(â) disease. These results could be used as reference for the evaluation of new drugs to treat R/R ALCL.