Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5527659 | Journal of Bone Oncology | 2016 | 4 Pages |
Abstract
Most deaths from solid cancers occur as a result of secondary metastasis to distant sites. Bone is the most frequent metastatic site for many cancer types and can account for up to 80% of cancer-related deaths in certain tumours. The progression from a discrete solid primary tumour to devastating and painful bone metastases is a complex process involving multiple cell types and steps. There is increasing evidence that modulation of the extracellular matrix plays an important role in the lethal transition from a primary to disseminated metastatic bone tumour. This review provides an overview of the current understanding on the role of role of lysyl oxidase, the extracellular matrix and the pre-metastatic niche in bone metastasis
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Authors
Alison Gartland, Janine T. Erler, Thomas R. Cox,