Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5530021 | Radiotherapy and Oncology | 2016 | 6 Pages |
Background and purposeConcurrent chemoradiation (CCRT) is the standard treatment for locally advanced anal canal carcinoma, although treatment-related side effects can affect patient quality of life (QOL). The purpose was to prospectively evaluate the effects of Tomotherapy (HT) based CCRT on patient reported QOL in locally advanced anal cancer.Patients and MethodsFifty-four patients treated with HT and concurrent 5-fluorouracil/mitomycin-C underwent QOL evaluation at baseline, after treatment, and during follow-up with EORTC core (QLQ-C30) and colorectal (QLQ-CR29) questionnaires. The QOL scores at baseline and post-treatment were compared.ResultsAll C30 functional symptoms, except emotional and cognitive functioning, were impaired end-of-treatment and recovered by 3Â months follow-up. The majority of symptom scores were worse end-of-treatment but recovered by 3Â months except for fecal incontinence (FI), diarrhea, urinary incontinence (UI), and dyspareunia which persisted. FI returned to baseline at 12Â months while diarrhea, UI, and dyspareunia persisted.ConclusionsMost impaired functions and symptoms following HT based CCRT were temporary and improved by 3Â months post-therapy. Late complications affecting QOL were FI, sexual function, UI, and diarrhea. Our observations support routine use of IMRT and emphasize the significance of precise evaluation of sexual, urinary, and anorectal functions before starting CCRT and routine incorporation of QOL evaluations.