| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 5530497 | Cell Calcium | 2017 | 7 Pages |
Abstract
â¢TRPV6 is one of the most Ca2+ selective Trp ion channels. It is mainly expressed in Ca2+-transporting epithelia e.g. epididymis and intestine, where it is assumed to play an important role in Ca2+ (re)absorption.â¢Furthermore, several human malignancies show an upregulation of the Trpv6 gene expression (e.g. prostate and breast cancer).â¢TRPV6 proteins are responsible for decreasing the Ca2+ concentration in the murine epididymal duct.â¢Thereby, lack of TRPV6 leads to an impaired function of sperm showing that is an essential determinant for male fertility.
Graphical abstractTRPV6 is essential for Ca2+ uptake in epididymal epithelia.Download high-res image (134KB)Download full-size image
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Authors
Claudia Fecher-Trost, Ulrich Wissenbach, Petra Weissgerber,