Review articleDirect control of B cells by Tregs: An opportunity for long-term modulation of the humoral response

Tregs are believed to be important for maintaining self-tolerance and immune homeostasis. It is well established that Tregs maintain self-tolerance and immune homeostasis by directly suppressing and modulating the effector function of T cells. However, there are a small number of studies that suggest Tregs also directly suppress and modulate B cells. Herein we review the literature that has investigated direct action of Tregs on B cell effector function. This area of study is intriguing because it suggests Tregs may influence long-lived humoral immunity.