Golgi ribbon disassembly during mitosis, differentiation and disease progression

•Golgi disassembles in mitosis via ribbon unlinking, unstacking and vesiculation.•Golgi ribbon disassembly is required for mitotic progression and spindle assembly.•Golgi ribbon disassembly often accompanies with microtubule remodeling.•During differentiation the Golgi ribbon disassembles to gain additional functions.•Fragmentation and dysfunction of the Golgi ribbon are linked to several diseases.

The Golgi apparatus is tightly integrated into the cellular system where it plays essential roles required for a variety of cellular processes. Its vital functions include not only processing and sorting of proteins and lipids, but also serving as a signaling hub and a microtubule-organizing center. Golgi stacks in mammalian cells are interconnected into a compact ribbon in the perinuclear region. However, the ribbon can undergo distinct disassembly processes that reflect the cellular state or environmental demands and stress. For instance, its most dramatic change takes place in mitosis when the ribbon is efficiently disassembled into vesicles through a combination of ribbon unlinking, cisternal unstacking and vesiculation. Furthermore, the ribbon can also be detached and positioned at specific cellular locations to gain additional functionalities during differentiation, or fragmented to different degrees along disease progression or upon cell death. Here, we describe the major morphological alterations of Golgi ribbon disassembly under physiological and pathological conditions and discuss the underlying mechanisms that drive these changes.