Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5531164 | Cytokine & Growth Factor Reviews | 2017 | 17 Pages |
â¢ROCKs and HDACs are relevant for tumorigenesis and neurodegeneration.â¢ROCKs and HDACs interact in normal and transformed cells.â¢Drugs against ROCKs and HDACs may combine favorably.
Rho associated coiled-coil containing kinases (ROCKs) respond to defined extra- and intracellular stimuli to control cell migration, cell proliferation, and apoptosis. Histone deacetylases (HDACs) are epigenetic modifiers that regulate nuclear and cytoplasmic signaling through the deacetylation of histones and non-histone proteins. ROCK and HDAC functions are important compounds of basic and applied research interests. Recent evidence suggests a physiologically important interplay between HDACs and ROCKs in various cells and organisms. Here we summarize the crosstalk between these enzymatic families and its implications for cancer and neurodegeneration.
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