Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
5534064 | Molecular and Cellular Endocrinology | 2017 | 24 Pages |
Abstract
G protein-coupled receptors (GPCRs) play a vital role in signal transduction. It is now clear that numerous other molecules within the cell and at the cell surface interact with GPCRs to modulate their signalling properties. Receptor activity modifying proteins (RAMPs) are a group of single transmembrane domain proteins which have been predominantly demonstrated to interact with Family B GPCRs, but interactions with Family A and C receptors have recently begun to emerge. These interactions can influence cell surface expression, ligand binding preferences and G protein-coupling, thus modulating GPCR signal transduction. There is still a great deal of research to be conducted into the effects of RAMPs on GPCR signalling; their effects upon Family B GPCRs are still not fully documented, in addition to their potential interactions with Family A and C GPCRs. New interactions could have a significant impact on the development of therapeutics.
Keywords
PTXPTHrPVPACGPCRPTHRCGRPECLCRFCTRGLPECDCaSRHEKCLRNHERF-1GPR30pTHGcgrG protein-coupled receptor kinasesGRKsadrenomedullinAmylinAMYHumanChoChinese Hamster OvaryCouplingExtracellular loopsextracellular domainramppertussis toxinSignallingcorticotrophin releasing factorTraffickingSalmonMouseRatparathyroid hormonereceptor activity modifying proteinvasoactive intestinal peptideparathyroid hormone related peptidecalcitonin gene-related peptideglucagon-like peptideCalcitoninhuman embryonic kidneyCalcium-sensing receptorparathyroid hormone receptorcalcitonin receptorGlucagon receptorcalcitonin receptor-like receptorG protein-coupled receptor
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Authors
Sarah J. Routledge, Graham Ladds, David R. Poyner,